Gulf Real Estates

Case Problem1: Bock investment Services The goal of Bock Investment Services (BJS) is to be the leading money market advisory service in South Carolina. To provide better service for their present clients and to attract new clients, BIS developed a weekly newsletter. BIS is considering adding a new feature to the newsletter that will report the results of a weekly telephone survey of fund managers. To investigate the feasibility of offering this service, and to determine what type of information to include in the newsletter, BIS selected a simple random sample of 45 money market funds.A portion of the data obtained is shown in Table below, which reports fund assets and yields for the past 7 and 30 days. Before calling the money market fund managers to obtain additional data, BIS decided to do some preliminary analysis of the data already collected. Managerial Report 1. Use appropriate descriptive statistics to summarize the data on assets and yields for the money market funds. 2. Dev elop a 95% confidence interval estimate of the mean assets, mean 7-day yield, and mean 30-day yield for the population of money market funds.Provide a managerial interpretation of each interval estimate. 3. Discuss the implication of your findings in terms of how BIS could use this type of information in preparing their weekly newsletter. Data for Bock Investment Services Money Market Fund Assets ($ millions) 7-Day Yield (%) 30-Day Yield (%) Amcore103. 94. 104. 08 Alger156. 74. 794. 73 Arch MM/Trust496. 54. 174. 13 BT Instit Treas197. 84. 374. 32 Benchmark Div2755. 44. 544. 47 Bradford707. 63. 883. 83 Capital Cash1. 74. 294. 22 Cash Mgt. Trust2707. 84. 144. 04 Composite122. 84. 033. 91 Cowen Standby694. 4. 254. 19 Cortland217. 33. 573. 51 Declaration38. 42. 672. 61 Dreyfus4832. 84. 013. 89 Elfun81. 74. 514. 41 FFB Cash506. 24. 174. 11 Federated Master738. 74. 414. 34 Fidelity Cash13272. 84. 514. 42 Flex-fund172. 84. 604. 48 Fortis105. 63. 873. 85 Franklin Money996. 83. 973. 92 Freed om Money1079. 04. 074. 01 Galaxy Money801. 44. 113. 96 Government Cash409. 43. 833. 82 Hanover Cash794. 34. 324. 23 Heritage Cash1008. 34. 084. 00 Infinity/Alpha53. 63. 993. 91 John Hancock226. 43. 933. 87 Landmark Funds481. 34. 284. 26 Liquid Cash388. 94. 614. 64 Market Watch10. 4. 134. 05 Merrill Lynch Money27005. 64. 244. 18 NCC Funds113. 44. 224. 20 Nationwide517. 34. 224. 14 Overland291. 54. 264. 17 Pierpont Money1991. 74. 504. 40 Portico Money161. 64. 284. 20 Prudential Money Mart6835. 14. 204. 16 Reserve Primary1408. 83. 913. 86 Schwab Money10531. 04. 164. 07 Smith Barnery Cash2947. 64. 164. 12 Stagecoach1502. 24. 184. 13 Strong Money470. 24. 374. 29 Transmerica Cash175. 54. 204. 19 United Cash323. 73. 963. 89 Woodward Money1330. 04. 244. 21 Case Problem 2: Gulf Real Estate Properties Gulf Real Estate Properties, Inc. is a real estate firm located in Southwest Florida. The company, which advertises itself as â€Å"expert in the real estate market,† monitors condominium sales by collecting data on location, list price, sale price, and number of days it takes to sell Sales Data for Gulf Real Estate Properties: Give View Condominiums No Gulf View Condominiums List Price Sale Price Days to Sell List Price Sale Price Days to Sell 495. 0475. 0130 217. 0 217. 0 182 379. 0350. 071148. 0135. 5338 529. 0519. 085186. 5179. 0122 552. 5534. 595239. 0230. 0150 334. 9334. 9119279. 0267. 5169 550. 505. 092215. 0214. 058 169. 9165. 0197279. 0259. 0110 210. 0210. 056179. 9176. 5130 975. 0945. 073149. 9144. 9149 314. 0314. 0126235. 0230. 0114 315. 0305. 088199. 8192. 0120 885. 0800. 0282210. 0195. 061 975. 0975. 0100226. 0212. 0146 469. 0445. 056149. 9146. 5137 329. 0305. 049160. 0160. 0281 365. 0330. 048322. 0292. 563 332. 0312. 088187. 5179. 048 520. 0495. 0161247. 0227. 052 425. 0405. 0149 675. 0669. 0142 409. 0400. 028 649. 0649. 029 319. 0305. 0140 425. 0410. 085 359. 0340. 0107 469. 0449. 072 895. 0875. 0129 439. 0430. 0160 435. 0400. 0206 235. 0 227. 91 638. 0 618. 0100 629. 0 600. 097 329. 0 309. 0114 595. 0555. 045 339. 0315. 0150 215. 0200. 048 395. 0375. 0135 449. 0 425. 053 499. 0 465. 086 439. 0 428. 5158 Managerial Report: 1. Use appropriate descriptive statistics to summarize each of the three variables for the 40 Gulf View condominiums. 2. Use appropriate descriptive statistics to summarize each of three variables for the 18 No Gulf View condominiums. 3. Compare your summary results. Discuss any specific statistical results that would help a real estate agent understand the condominium market. 4.Develop a 95% confidence interval estimate of the population mean sales price and population mean number of days to sell for Gulf View condominiums. Interpret your results. 5. Develop a 95% confidence interval estimate of the population mean sales price and population mean number of days to sell for No Gulf View condominiums Interpret your results. 6. Assume the branch manager requested estimates of the mean selling price of Gulf View condominiums with a margin of error of $40,000 and the mean selling price of No Gulf View condominiums with a margin of error of $15,000. Using 95% confidence, how large should the sample sizes be? . Gulf Real Estate Properties just signed contracts for two new listings: a Gulf View condominium with a list price of $589,000 and a No Gulf View condominium with a list price of $285,000. What is your estimate of the final selling price and number of days required to sell each of these units? a: sample mean +/- 1. 96*(st dev/sqrt(n)) 454222. 5 +/- 1. 96*192517. 75/sqrt(40) 394560. 6312 513884. 3688 The 95% CI is ($394,560. 63, $513,884. 37). Using Excel: 59660. 7736 $394,561. 73 $513,883. 27 The 95% CI is ($394,561. 73, $513,883†¦ Case Problem 3 Metropolitan Research, Inc. Metropolitan Research, Inc. a consumer research organization, conducts surveys designed to evaluate a wide variety of products and services available to consumers. In one particular study, Metropolitan looked at consumer satisfaction with the performance of automobiles produced by a major Detroit manufacturer. A questionnaire sent to owners of one of the manufacturer’s full-sized cars revealed several complaints about early transmission problems. To learn more about the transmission failures, Metropolitan used a sample of actual transmission repairs provided by a transmission repair firm in the Detroit area.The following data show the actual number of miles driven for 50 vehicles at the time of transmission failure. 85,092 32,609 59,465 77,437 32,534 64,090 32,464 59,902 39,323 89,641 94,219 116,803 92,857 63,436 65,605 85,861 64,342 61,978 67,998 59,817 101,769 95,774 121,352 69,568 74,276 66,998 40,001 72,069 25,066 77,098 69,922 35,662 74,425 67,202 118,444 53,500 79,294 64,544 86,813 116,269 37,831 89,341 73,341 85,288 138,114 53,402 85,586 82,256 77,539 88,798Managerial Report: 1. Use appropriate descriptive statistics to summarize the transmission failure data. 2. Develop a 95% confidence interval for the mean number of miles driven until transmission failure for the population of automobiles with transmission failure. Provide a managerial interpretation of the interval estimate. 3. Discuss the implication of your statistical finding n terms of the belief that some owners of the automobiles experienced early transmission failures. 4. How many repair records should be sampled if the research firm wants the population mean number of miles driven until transmission failure to be estimated with a margin of error of 5000 miles? Use 95 % confidence 5. What other information would you like to gather to evaluate the transmission failure problem more fully?

Is Torture Reliable or Humane? Essay

Imagine being forced into confession with your head down, and blood rushing to your brain. Picture the struggle of being held down and defenseless, against your will. Imagine having a thick towel pressed firmly over your face and continuous water being poured on the towel as you helplessly gasp for air simulating the effect of drowning. Imagine being bound and thrown into the ocean with a ‘weight’ that pulls you in only one direction: down to the bottom of the ocean floor. Do you think this kind of action is right to do to a criminal or let alone a human? Torture is the action or practice of inflicting severe pain on someone as a punishment in order to force them to do or confess something. History has changed from uncivilized torture techniques to civilized torture and then back again. There has been crucial maltreatment on prisoners and suspected criminals. The crucifixion of Christ by the Romans is a huge example of torture. The Romans beat and whipped Christ, pinned his hands and feet with needles onto a wooden cross, and put a thorny crown around his head. Back then, even great thinkers defended torture saying it was protecting civilization, and bringing control to the people. They had no limit to who they were torturing. The Romans began to create laws allowing only certain subjects and crimes that could entail torture, but as time passed they added more subjects to the availability of torture. Christianity later became the commanding force and went against all the torture laws, and fought hard to change the way torture was executed. Once the September 11 attack happened, people forgot about human rights because they were fearful of another attack, so they continued the use of enhanced interrogation techniques. Torture was used because people believed it to be an effective way to extract information from a captive suspect. The United States police mentality and parents cause children to think that torture is justifiable. When 9/11 happened the United States became defensive and feared the thought of another terrorist attack. We were willing to do anything to find out who the culprit was. We wanted to feel like we had national security and we needed someone to blame, so if torture techniques were the solution, we were willing to do so. Blinded by the tragedy that tools place, we were not using our intelligence. The United States was taking action based on fear and revenge, torturing suspects, and affiliates. The result from this will cause the safety of the nation to be at a higher risk of an attack. The media is another factor to the use of torture. Jane Mayer wrote in her article â€Å"Whatever it Takes† about a TV show called â€Å"24†. 24 was a television show that was all about torture, but instead of showing how torture was wrong, the show glamorized it. The show displays torture as being a useful tactic to make people talk and almost all the people that watch the show get conned into thinking the same way. The sad part of the story is that even children watched the show 24: â€Å"The kids see it, any say, ‘If torture is wrong, what about 24’† (261). The show was convincing and one sided, being torture is justifiable and effective, that people believed it was true, but Jane disagreed with it. She thinks that it only works in some cases, but there are down sides to using torture, such as misguided information. Torture is displayed widely around the world in a positive way, but they do not see the negative effects of using torture techniques to solve problems. Torture can cause long term effects on torture subjects. Physical and mental actions can harm a person for the rest of there life. Most survivors of torture suffer post-traumatic stress syndrome – a severe anxiety disorder. In David Masci article â€Å"Should it be used to interrogate suspected terrorist?† he interviewed a women named Dianna Ortiz that is a survivor of torture tactics. Dianna suffered mentally from the torture experience; â€Å"nightmares, flashbacks and fear shadowed me everywhere. And I had trouble with my memory. I couldn’t recognize the people who were closest to me before my torture. I couldn’t articulate what was happening to me†¦ I thought I was going crazy†(Masci). Dianna was damaged; she could not live her normal life. The fear of being tortured taunted her. Almost all or even all suspects suffer post-traumatic stress disorder. Head injuries are also a common injury due to the different torture techniques used, as well as afflictive impairment, chronic pain, extensive sensory and memory loss. The prisoner will even be incapable of performing our daily activities: dressing, cooking, and sleeping. Torture is a dangerous, unreliable, and slow practice and can be stopped through accountability of the torturer. The torturer must provide a humane setting for the prisoner, question the prisoner with interpersonal evidence, and use his intelligence and technique to decipher the truth in an adequate way. Many people think that torture is the most effective interrogation strategy, but know very little about the torture techniques being used on prisoners. Society does not think of the inhumane violence that occurs when torturing a prisoner of war. By releasing failure torture techniques and vivid descriptions on the methods such as, water boarding, electrocuting, sleep deprivation, and solitary confinement, the society will see the truths and horrors of torture. In reference to David Masci article â€Å"Should torture be used to interrogate suspected terrorist?† he addresses different examples of terrorist techniques, one being â€Å"[Prisoners] were [being] stretched on the rack or subjected to leg or thumb screws†(Masci). What kind of treatment is this? Inhumane treatment. Prisoner’s rights are being blurred out and ignored. Animals do not even receive punishment like this, for the most part. Torture overpasses our human rights to interrogate prisoners and try to make it justifiable, but it is not. Even if the interrogator got an answer- true or false- from the prisoner, the actions the interrogator did are not right and will cause damage on not only the prisoner, but also the interrogator. This inhumane method of interrogation has been proven to work adversely in situations of torture and is unjust to do to anyone or anything. It can lead our people to realizing that torturing someone isn’t the only way to get what you want out of them. In order to coerce the prisoner to speak based on intelligence, the interrogators must have prior knowledge about him or her. When the interrogator first starts to interrogate the detainee, they must set him or her in a comfortable environment. Of course, the prisoner will have hatred and unwillingness for the United States to begin with; the United States must keep the interrogation in control. We must appeal to the prisoner, giving him hope of being free again. There was a story on Abu Jandal; Ali Soufan treated Abu Jandal with cookies when questioning him. Soufan noticed that Abu Jandal had not eaten the cookies, so he knew he had to fix something to treat Jandal. Soufan found out Abu Jandal was a diabetic, so in response to that, the next time the Americans questioned him, they brought sugar-free cookies. Giving Abu Jandal the cookies, Soufan found a change in the rest of the interrogation. Abu Jandal â€Å"could no longer think of us as evil American† as he did before he received special treatment (Tom Parker). Americans had expressed a respectful environment for Abu by providing him with sugar-free cookies that were fixed towards his health. The interrogators could have easily used his diabetic condition against him in a form of torture, but instead they chose to use a less inflicting technique, by appealing to his emotions. Abu Jandal now felt an obligation to inform the United States in turn of there kind treatment. He later â€Å"gave up a wealth of information about al-Qaeda — including the identities of seven of the 9/11 bombers†(Tom Parker). This information was vitally accountable in preventing any future attack on the United States. This interrogation technique used by the interrogator appealed to health and preference of the detainee to connect with him resulting in beneficial information. Another problem with torture is that fact that the information being given is not reliable. When a prisoner of war is being tortured and is at the point where he or she can not take any more pain, they say anything to get the interrogator to stop. The United States of America used torture techniques on al Libbi and the results from that misled our army, and potentially wasted our time and resources following a false lead, leaving leeway for Iraq to finish their attack. Torture does not yield accurate resolute. Torturing techniques fuel terrorist, put American soldiers at risk, and ruin America’s moral authority. When the prisoner of war is tortured they say anything to stop the torture from continuing, but almost always give false information, as al Libbi did. The torture technique interrogator does not have accurate information on the prisoner of war, so when the interrogators are given information they have no choice but to go with it, which can lead to even more conflicts in the process. When society turns against torture they will be open to alternative interrogation techniques that may have more effective results. Once the prisoner is in a comfortable environment, we can then start to question him or her. Prisoners are trained to resist the torturous techniques, but not trained or able to go through a questionable approach of interrogation. Prior to the interrogation, the interrogator must find valuable knowledge about the detainee to use against him or her. Mental abuse is to an extent a way of torture, but in the way the informed interrogators used the mental interrogation, it would not be considered torture. The informed interrogation approach is based on influencing our knowledge of the prisoner’s culture and mentality, combined with using known facts about the prisoner (Soufan). Having heard your child or family is captured or is at risk, is an example of mental torture. Ali Soufan, a security consultant and former investigator for the FBI, was involved in the investigation of Abu Zubaydah interrogation. Soufan discussed in his article â€Å"Is torture ever justified?† about two methods of interrogation, the informed interrogation approach and the enhanced interrogation technique. Ali Soufan asked for his name and he gave him a false name, so then Soufan used his investigation to work against Abu Zubaydah. He asked to call him by his nickname Abu’s mother used to call him, Hani (Soufan). Abu now had the thought of Americans having more information about him, so he could not give them false information. Research shows, when the United States asked him questions he started to give out answers involving KSM the mastermind of the 9/11 attack. Using this mental tactic was in no ways a type of torture because Abu Zubaydah was not harmed mentally, he just had the fear of lying and getting caught, resulting in reliable and useful information. Often times, torture techniques are slow: â€Å"preventing a detainee from sleeping for 180 hours as the memos detail, or water boarding 183 ties in the case of KSM† (Soufan). This method would not work in the â€Å"ticking time bomb† scenario because it does not get quick results. It takes time to torture a person, especially a prisoner of war. Although some people can handle pain more than others, the prisoner, if a culprit to the crime will be notably able to resist an abundant amount of pain. The prisoners go through training school that practice torture techniques. When your body gets used to pain, it can resist the pain for a longer period of time. Not only can the prisoner resist the pain longer, the torture techniques do not work quickly. For instance, sleep deprivation must take at least 24-48 hours to kick in. Sleep deprivation is also one of the first method used often times when interrogating the prison. Statistics show that when people are restless their brains do not work productively and can not think on the spot, so when being asked questions it will take the prisoner time to answer, if they are willing to answer in the first place. Therefore, getting information fast will not result from torture, but it will from the informed interrogation technique. The informed interrogation approach has work time and time again. Abu Zubaydah is a perfect example of the technique because he proved it effective. The investigators first approached him in an informative way. They used the background information they already knew about him, to make him fear giving them the wrong information and that took them about two hours to get information from him. After Soufan, the CIA took over the investigation and started to use torture tactics on Abu Zubaydah. The torture tactics did not produce any results. The CIA spent plenty of days and hours using different torture techniques to potentially obtain information, but he still would not give up any information. The investigators just hospitalized him, so once again Washington returned to the FBI agent and Soufan to continue the interrogation. Working with Abu Zubaydah’s conditions, the FBI agent and Soufan continued their questioning. They again were successful and got Abu Zubaydah to tell them more information, but once again, the CTC-Counter Terrorism Center- arrived and took over the interrogation. Harsh interrogation techniques were used one Abu Zubaydah, beginning with public nudity. The torture techniques kept making Abu Zubaydah uncomfortable, hurt, and angered. The technique was not working. The CTC used worse and worse torture technique, but still nothing came out of Abu Zubaydah because they did not treat him humanly. Washington noticed there were no results to the torture techniques, so they decided to go with the informed interrogation approach. The FBI agent and Soufan gathered more actionable intelligence from Abu Zubaydah in less then a couple hours (Soufan). This is one of the many proofs that the informed interrogation approach does result in reliable answers. Obtaining information quickly can be important when involving a â€Å"ticking time bomb† scenario, and after these studies of both techniques, you can see which one had a quicker, effective on the prisoner of war. Torture techniques are harmful, slow and unreliable. The solution to this problem is adapting the informed interrogation technique. The interrogator must do their research to have extensive knowledge about the prisoner. They must grant the prisoner a safe environment, perform civil treatment towards the prisoner of war, and question the prisoner critically and use evidence the investigator has about the prisoner to obtain information. All these steps will help prevent torture. Since there are alternative solutions that have been proven to work, then there is no need to use torture. Torture is evil; it inflicts pain on a human purposefully for questions and answers that have a high possibility of being false. Torture techniques are inhumane. We are humans and should be treated as humans.

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The Incredible India - Research Paper Example It is also a country where marriage and family are regarded almost as a requirement for a full and happy life. Please join me in attempting to scratch the surface of the seventh largest country in the world, as together we uncover exciting facts about the country and the people that live within it. The Incredible India Introduction India, once a colony under the rule of Great Britain, is today an independent country with its own government, society, and culture. It is the seventh largest country in the world and in 2005 claimed the feat of being the second highest in population (Daniel, 2005). To the world, it is officially known as the Republic of India (Daniel, 2005). It also has two other names including Bharat from the Sanskrit language as well as Hindustan, a name given by the Persians meaning people living near the river Indus (Daniel, 2005). To the people of the country, it is simply called India (Central Intelligence Agency, 2012). It has six border countries, including Nepal , Burma, Pakistan, Bangladesh, Bhutan, and China, some of which were formerly part of what was known as the colony of â€Å"British India† (Central Intelligence Agency, 2012). ... gh India achieved its independence on the 15th of August 1947 after a very long struggle, the last of the British troops did not leave until 1950 (Daniel, 2005). Until its independence in 1947, the present day neighbors of Pakistan, Bangladesh, and Myanmar were all a part of what was known as â€Å"British India† that included what is today the country of India, and were ruled under the concept of â€Å"divide and rule†, which split the areas into many different communities and offered absolutely no sense of nationalism whatsoever (Daniel, 2005).When it became clear that the British were going to leave, India demanded to be made into separate states that each reflected their own religious and political beliefs (Daniel, 2005). The problem was finally solved when two nations were created, India and Pakistan, which continue to this day (Daniel, 2005). India, like many other countries, also had their capital moved by their imperial rulers. The former capital of India was Ko lkata (Calcutta), situated in the east of India (Wright, 2011). However, in 1911, a letter was written by the Viceroy of the country under British rule that endorsed the idea of moving the capital to New Delhi (Wright, 2011). Among the reasons given was that, due to the Morley-Minto reforms, the Indian people were allowed to hold legislative positions (Wright, 2011). This fact meant that a more central capital was needed (Wright, 2011). However, behind the scenes, a storm was brewing, and the movement to give India its independence had gained strength, most notably in Calcutta (Wright, 2011). It was felt that a more hospitable and new city was needed in order to protect the sanctity of the rule, and therefore the capital was moved to New Delhi (Wright, 2011). The city was built for the purpose of holding

Can Globalization Be Reversed Essay Example for Free

Can Globalization Be Reversed Essay With the coming of the industrial age, the wheel of progress turned. Factory based mass production replaced independent artisans, who now worked for business firms (Volti, 2009, p. 187). The workers became dependant on businesses to provide facilities to work in, tools to work with, and wages to take home, creating a society of employees (Volti, 2009, p. 187). Since work and income was now dependant on the factories, workers need to find homes in relative proximity, thus leading to higher density of individuals within the urban areas surrounding the manufacturing centers. With urbanization came a need for production and transportation of food to the growing cities. In the 18th and early 19th centuries, this food was generally produced locally on the surrounding farmlands with only the occasional delicacy imported from a foreign land. While factory work was hard and the hours long, people chose it over subsistence farming as it lead to a better standard of living for themselves and their offspring. Bertha Black remembers her family’s move to a mill town: We all went to work, in the Amazon Cotton Mill and we all worked there all our lives. We were all anxious to go to work because, I don’t know, we didn’t like farming. It was so hot from sunup to sundown. No, that was not for me. Mill work was better. It had to be. Once we went to work in the mill after we moved here from the farm, we had more clothes and more kinds of food than we did when we was a farmin’. And we had a better house. So yes, when we came to the mill life was easier (Rivoli, 2009, p. 110). Thus began urbanization which continues to this day, with 50% of the global population residing in urban centers (Satterthwaite, 2010, p. ). This urbanization is directly coupled with wealth, where the â€Å"more urbanized a country, the higher the individual incomes (Satterthwaite, 2010, p. 1)†. The United States, one of the top 20 global incomes per capita (World Bank, 2011, p. 1), supports this, as 82. 1% of the population live in urban centers (Satterthwaite, 2010, p. 2). Urbanization trends have been linked to enhanced democracy, technological innovations, economic progress, and higher living standards (Satterthwaite, 2010, p. 2). Is it any wonder then that â€Å"[n]o matter the path of economic development a country has chosen, urbanization remains an inevitable outcome of this effort across the world (Satterthwaite, 2010, p. 1)†. As the living standards and population densities of urban centers increase, so too do the distance that food needs to be transported. Today, a large urban center, like the greater New York City metropolitan area with a population of over 21 million people (US Census, 2010), has to reach to great distances for its food. This is because 1. acres of arable land are required per person to maintain the diverse diet American’s enjoy (Pimentel Giampietro, 1994). This translates to 25. 2 million acres of arable land being required to feed New York City. Thus 7% of the US population (US Census, 2010) requires 10% of America’s farmland (USDA, 2012, p. 56). It should come as no surprise then that our agriculture imports exceeded $94 billion in 2011 (USDA, 2012, p. 90). The comparative wealth of the American populace, coupled with their culinary desires leads to a demand for imports of produce and other horticultural items during the off seasons in the US. Put another way, Americans’ desire for fresh tomatoes on their Del Taco tacos in February in the American northeast drives global trade to farmers in Central and South America. The motivation of the labor market, to increase quality of life, explains the willingness of individuals to accept factory work and their desire to progress to better, higher paying jobs. Neo-classic economic theory explains business motivation to achieve maximum profitability through efficiency of production (Weintraub, 2002). Efficiency is maximized through three inter-related and adjustable parameters: technology; labor; materials. Technology, as expressed in terms of facilities and equipment, is a fixed cost of production, whereas labor and materials, including transportation expenses, remain variable costs (Starr, 2008). In achieving the optimal balance, any large discrepancy will heavily weight the calculation. For example, the wages for textile workers in southeast Asia are 7% of the wages in United States (Rivoli, 2009, p. 104). This large of a differential in the variable cost makes it virtually impossible to create an equivalent model through enhanced technology, especially when most technology advances can be applied to factories located in the lower labor cost countries. Thus Rivoli’s â€Å"Race to the Bottom† continues (Rivoli, 2009, pp. 92–104), bringing with it industrialization and urbanization. As with any race, there are winners and losers. The countries acquiring the manufacturing jobs and the companies maximizing their profits through relocating manufacturing to the lower labor cost countries are obvious winners. The employees of the factories being off-shored are initially the losers, until the race progresses to the next industrial sector. A clear example of this is the Carolinas, where many textile worker’s jobs have been lost to southeast Asia, now have opportunities for better paying jobs in auto manufacturing. BMW opened a plant in Spartanburg, SC, the middle of the cotton belt, which generates over $1. 2 billion in wages and salaries annually (Ramsey, 2009). Thus the race continues, moving from industry to industry, as total production cost dominates companies’ decisions on where to locate manufacturing. However, many of those losing their jobs in America raise the cry to stop globalization, reconstitute local manufacturing and local food markets. This would not appear to be a feasible alternative for three reasons. First, the degree of urbanization present in the United States makes it unreasonable to expect food to be produced locally. Similarly, the relative wealth and current lifestyle lead many to expect and demand fresh produce year round. Together, these preclude a shift to locally grown and produced foods. Second, most companies in America today have some aspect of globalization present in their value chain. This can be upstream in their suppliers of materials and/or equipment or downstream in their customers. This is readily apparent in large corporations, such as Nike and WalMart, but it is also present in smaller companies. Rygaard Logging, Inc. out of Port Angeles, Washington is a good example. This small company relies on equipment imported from South Korea and Germany to harvest logs. China has become the largest buyer for timber from the northwest, thus becoming an attractive customer for Rygaard (Springer, 2011). Unwinding these value chains to bring manufacturing back to America may be possible, but would require the will of politicians in Washington to face the public backlash as prices increased, and selections decreased (Rivoli, 2009). Third, the growing population requires more land be utilized for their living and working environment. Current estimates show each person in the US consumes one acre for housing, work facilities, and supporting infrastructure (World Bank, 2011). Further, the current population growth is over 50,000 new people per week (Pimentel Giampietro, 1994), meaning that over 2. 5 million acres of arable land or bio-diverse forest land is lost annually, increasing the pressure on food production. Plus, these people are generally employed by firms that rely on globalization in their value chain, as described above. Together, these factors make it highly improbable that the US can return to 100% locally produced foods and companies whose value chain resides 100% within America’s boarders without significant changes in lifestyle.

Social Work Management in Youth and Communities

Social Work Management in Youth and Communities 1.0: Introduction Youth work in the community, which is mainly performed by specially trained youth workers who work with youth at risk in group homes and community centres demands a high level of managerial skills blend with the skill in social work as argued by Mark Krueger (2000)[1]. The fact that the youth work is a non-profit approach makes it clear that the established management concepts were successful in profit-based organization need necessarily prove effective when deployed. In this report an overview of the theories embracing the management and social work with regards to youth and community work is presented to the reader. The report also demonstrates relevant examples from my previous experience in order to justify that the author of this report is ready to perform as an autonomous and reflective practitioner in the area of youth and community work. Furthermore, the report also presents a critical analysis on the British Social policies and the European Union perspective. A brief review on the global view on the youth work is also presented before concluding the report. 2.0: Overview of the theoretical concepts embracing youth and community work with examples This section commences with the overview on the management and historical content that reflects upon the youth work is presented to the reader. This is then followed by the analysis of the information and control system where the importance of the planning and information management is presented to the reader. The section is then concluded with an overview on the human resource management concepts embracing the youth work. 2.1: Management and historical content Peter F. Druker (1990)[2] says that management in the non-profit context is not only about effective performance and development but mainly embraces the idea of value addition to the society. The fact that the non-profit organizations are increasing in number with the support from government and public as argued by Robert F. Ashcraft (2000)[3]. This is not only because of the fact that the non-profit organizations are focused upon charity and fund raising but also involves the development of people at risk. The youth at risk development, which is of interest in this report, was given high level of importance only since the dawn of the twenty-first century even though it was emphasised by many researchers as early as 1978 by Paul Osterman (1978)[4]. As stated before, youth work in the community is a non-profit approach where the aim is to provide support and development to the youth at risk. This makes it clear that the nature of the work involved is varied and hence management skills that embrace the social work and value addition are essential than the effective performance managers who fair well in the profit-based organizations. Furthermore, it is also interesting to note that the youth work is not always about the social work to revive youth in danger but also to provide value-added service to the community in order to develop the youth of the nation through imparting culture and discipline. Alongside, it is also an intriguing fact that even through the youth work is a non-profit approach, the investment involved with the setting up and the running costs of the community work are relatively high with negligible or no income being generated. The support by the government and the local city council being the major source of the support financially, the management skills of the youth workers should not only embrace the efficient cost management methods but also focus upon developing the effective relationship strategy with the community in order to involve the neighbourhood to support the community work morally or even financially as argued by Mark Krueger (2000). The fact that youth work is predominantly involves the counselling, teaching and caring for the youth who come to the youth shelter having been abused, or in need of respite from home. In these cases the managerial skills of the youth worker should be more empathetic than focusing upon the development. The soft skills of the management like patience, proactive management to support people in need are the essential elements of management that should be demonstrated by a youth worker as argued by Mark Schoenhals (1998)[5]. This justifies that the effective management in the social work context is not about performance but mainly about the deployment of the soft skills to support the youth in need. Alongside it is also essential to mention that the youth worker’s management skills should not only reflect upon the development of the youth but also to focus upon the entire neighbourhood the youth worker is working at as argued by Mark Krueger (2000)[6]. The fact that the youth worker predominantly working in a volatile environment (i.e.) an unstable work place like the temporary youth shelter, working with the parents, foster parents etc as identified by Mark Krueger (2000) makes it clear that the youth worker management skills should be versatile to accommodate the changes in the environment effectively. The author’s experience from working with the Coventry Youth service has justified the aforementioned argument where the author gained experience of working with the Asian community youth in Hill-fields are of Coventry. Alongside, the student development programme conducted at Binley area which was focused upon the development of the youth through working with the parents and foster parents of the youth is another justification that the versatile management skills that embrace the soft skills is essential for the successful development of the youth work. It is also critical to state here that the author who led the youth development programme at Binley with a team of six youth workers accomplished the goals of the project (provide support and development opportunity to the youth in the community through working with their parents or foster parents) through the efficient deployment of the management skills discussed above. 2.2: Information and Control system Information and control in the youth work is a critical element in order to achieve the goal of providing development services to the youth. This is mainly because of the fact that the youth worker having to face a varied environment requires accurate and comprehensive information so as to effectively deploy the development plan. Mark Krueger (2000) argues that the information is a vital element for the successful planning of the development plan in a give youth and community work scenario. This is not only because of the need to effectively deploy the resources but also to accomplish the goal of the youth work that is projected for the day. Alongside, it is also essential to note that the control over the youth work is essential in order to accomplish the set goals of the project on hand without wastage of time and resources. Sara Banks (1998)[7] argues that the youth work in a community should be deployed in a controlled manner reflecting upon the ethical conduct and code of ethics mainly because of the fact that the youth work itself involves the deployment of self-discipline and control by the youth worker who strives to set an example of himself to the youth community he/she targeting to reform or protect. The fact that the control in the youth work is not the control of the youth but the stages of the programme being deployed makes it a critical that the information gathered is accurate and effective in nature. The information being the vital ingredient for the deployment of a plan in the youth work as argued by Sara Banks (1998) further justifies that the youth work should comprise effective background research on the community targeted prior to planning. Sara Banks (198) further argues that the information research and the planning can be accomplished effectively and successfully deployed through closely working with the city council and the local community centres by which the youth worker enjoys higher level of support and help from the community. Sara Banks (1998) also state that stating the objective of the youth work for a particular project is the critical element for the successful planning itself. This is also justified by the arguments of Abraham Daniel (1999)[8] who says that the objective of the youth work is the main element that attracts the community to participate in the youth development programme by the youth workers. Apart from the objective setting the factors of planning and evaluation are essential in order to deploy the resources since the plan of the youth work devised can be accomplished only through the effective evaluation of the information and plan in the light of the needs in the community targeted. The youth work participated by the author at Shotton in North Wales where the major barrier was the language because of the predominant Welsh population in the community. Alongside the cultural differences faced by the author and his team members along with the language barrier was overcome only through the effective information research on the community and closely working with the city council. The objective of the work being the rehabilitation of the youth who were under drug abuse was effectively planned through the effective information gathering on the activities of the youth in the community as well as the involvement of the local community centres to support the planning of the project. Furthermore, it is also essential to mention that the author who was the team member during the deployment of this project was given the opportunity of planning the work along with the team leader. It was clearly evident from the experience gained that the efficient planning is an essential el ement for the successful deployment of the youth work on hand. Alongside, the work at Shotton also provided valuable experience on the development of the controls around the project and the targets to meet in order to effectively accomplish the revival of the youth from drug abuse in the community. Since the project was initially misinterpreted as a rehabilitation project than support to the community, the marketing and communication of the project objective as a supporting element to develop the youth in the neighbourhood rather than a rehabilitation school. The process of working closely with the local community centres and the city council was highly supportive to achieve the confidence and support from the parents and foster parents of the youth. This is synonymous to the arguments of Philip Kotler and Kevin Lane Keller (2005)[9] who argue that the marketing communication is the vital tool for successfully reaching the target customers both in case of the profit-based and non-profit organizations. The discussions cited above comprise a vital example for the critical nature of the information and control in the youth work. 2.3: Human Resource management in youth work Human resource in any kind of work is indispensable in nature as argued by Derek Torrington and Laura Hall (2003)[10]. This is apparently because of the fact that the effective performance of the personnel involved in the project is the kindling element for accomplishing the project goals. This is also evident from the arguments of Michael Armstrong (2003)[11] who emphasises the fact that the human resource especially in a non-profit scenario is the foundation pillar for the entire project itself. The fact that the motivation and encouragement in the youth work or in any other form of social work is only through the effective leadership skills of the team leader who has to consider that the motivation is purely moral in nature and does not always include financial benefits. This apparently means that the leadership skills of the manager managing the project should be exemplary and must also demonstrate flexibility along with the authority and control. This is essential because of the volatile nature of the community work and the continuous changes that can affect the performance of the team members in involved in the community work. Andrew Rothwell and John Arnold (2005)[12] argue that the human resource management in a non-profit scenario and mainly the performance management are dependent upon the level of authority and control exercised by the manager in deploying the resources. This is also because of the fact that the results are not easily measurable in case of youth and community work, which makes it critical to understand that the performance of the youth workers is predominantly dependant upon their adherence to the controls and effectiveness in deploying the plan. Alongside, the authority element as argued by Mark Krueger (2000) is also an element of management and influence among the team members mainly because of the fact that the managers in the youth and community work do not have direct supervisory control over the team members since they work in a dispersed nature within the community under consideration itself. This makes it clear that the effective management can be accomplished only through the effective exercise of the authority. Furthermore, the fact that the youth workers and the youth with whom they work comprise the overall project plan makes it a complex job to effectively manage the youth worker to demonstrate self-discipline and character so as to set an example in the youth community they work. This being an essential element for the success of the youth and community work project is the major element that attributes to the human resource management by the managers in the youth work. Unlike the profit-based organization the non-profit approach with the need to demonstrate empathy and maintain effective relationship with the community makes it further critical for the managers to deploy a structured approach to the management of the youth and social work as argued by Peter F Druker (1990). A structured approach will not only enhance the performance of the youth workers but also help accomplish the objectives of the project effectively. This is also evident from the need to effectively organize the resources in order to accomplish the objectives as well as establish effective relationship with the community. The fact that the relationship with the community can be effectively nurtured through the structured deployment of the project by the managers emphasises the importance of the structured approach and performance management in youth and community work. The learning development project by the author and his team members at Tividale, in Dudley port at Birmingham is a classical example for the aforementioned discussions. The author being the team leader not only faced the language and cultural barriers but also a level of non-cooperation by certain community centres. Since the population in the target community was of diverse origin the need for a structured approach was essential to accomplish the planning and information research stages itself. This is not only because of the structured deployment but also through the effective deployment of the human resource (i.e.) management of the team members. The team had an inherent advantage of inclusion and diversity since the members were of different origin working for the same goal. This was effectively utilised to liaise with the community centres and gather required information and involvement to the project. The management of the members through the exercise of authority for example t he emphasis on working for target by the author was the factor that contributed to the effective performance among the team members. Furthermore, the planning and deployment of the project through allocating each team member a team of youth and an attached community centre also proved successful to the youth work as well as motivating to the youth worker. The effective planning process, which provided effective management as well as accomplishment of the targets within the time frame agreed, helped to the success of the project greatly. From the above discussions it is clear that the author of the report has strived to demonstrate a clear understanding of the management theoretical concepts with examples from this experience gained through fieldwork. In the next section a critical analysis on the big picture of the British Youth policies and comparison to that of the European Union and a global perspective is presented to the reader. 3.0: The big picture The British youth policies as argued by John A. Calhoun (2002)[13] is predominantly rehabilitation based (i.e.) the use of law and order to accomplish the youth development can be seen in the system. Although the youth development in the UK embraces the welfare of the youth, the stringent laws present on the Binge drinking and other anti-social activities that results in cash penalties and even imprisonment makes the youth policy a little overstated in the UK. Bill Katz (2004)[14] further argues that the policies adhered in the UK is not only the critical element for the successful deployment of youth and community work in the society but also establishes the need to establish trust among the public in order to gain their co-operation. The British youth policies in general even through as stringent laws is focused upon the overall development of the youth community in the UK in order to present an effective and sustainable environment for the future. This approach of the government is necessary because of the increasing diversity in the population in the UK. The interesting fact that the diversity in the UK population has not tarnished the support by the community to government’s strive to youth development but is also against the use of force and law against youth accused for anti-social activities. The need for self-discipline and control in the society as stated by John A Calhoun (2002) makes it clear that the need to use force when necessary to accomplish the aforementioned is inevitable. Furthermore, an insight into the Greater Manchester Metropolitan Police report (2004)[15] makes it clear that the use of force is the last used method to control anti-social behaviour by the youth involved in anti-social behaviour. This further makes it clear that youth policy both at the local and national level use force to control anti-social behaviour of youth as a last sought method rather than using it in the first instance. This justifies the youth policy of the nation, which is focused upon the development of youth and protection from abuse whilst exercising force when involved in anti-social behaviour. The youth policy proposed by the European Union is similar to the approach of UK except for the emphasis on the use of force on youth. The policy not only reflects upon the need to provide development and support to the youth but also emphasises upon the restricted use of force in by the authorities. Since the approach of European Union embraces the member states it is thus essential to emphasise upon the restriction on the use of force. This is because of the varied nature of the exercise of law and order across European Union member states thus making it essential to prevent the use of force on the youth. It is also intriguing to note that not only the western countries are involved in the youth development and support but also the countries in the Far East like China and India. The Chinese government approach to youth development as a critical element for the economic growth of the nation makes it clear that the Far eastern countries have realised the importance of youth development in order to sustain the economic growth of their nation. 4.0: Conclusion Thus to conclude this report, it is clear that the management of youth and community work by the youth workers and managers is a challenging role that requires versatile people skills blended with effective management and planning. The overview on the theoretical concepts and the examples has revealed the author’s understanding and knowledge in managing youth and community work. The overview on the big picture detailing the British youth policy and the European Union has also justified the extent of research conducted in order to establish as an autonomous and reflective practitioner in the area of youth and community work by the author. 5.0: References Books Derek Torrington and Laura Hall (2003), Personnel Management HRM in Action, UK: Prentice Hall Michael Armstrong and Tina Stephens (2003) A handbook of employee reward management and practice, London Kogan Page Peter F. Druker (1990), Managing the non-profit organization: practices and principles, London: Butterworth-Heinemann Philip Kotler and Kevin Lane Keller (2005), Marketing Management 12e, Prentice Hall India Journals and reports Abraham Daniel (1999), ESTABLISHMENT OF INDUSTRIAL CO-OPERATIVE UNITS. Annals of Public Cooperative Economics, Vol. 42 Issue 2, p169 Andrew Rothwell and John Arnold (2005), How HR professionals rate continuing professional development Human Resource Management Journal, 2005, Vol. 15 Issue 3, p18-32 Bill Katz (2004), Youth Policy: The Monthly Report on National Youth Program and Issues. Library Journal, 4/1/89, Vol. 114 Issue 6, p119-119 Greater Manchester Metropolitan Police (2004), Performance Statistics John A. Calhoun (2002), Claiming youth: A new paradigm in youth policy. New Directions for Philanthropic Fundraising, Winter2002, Vol. 2002 Issue 38, p67-80 Mark Krueger (2000), Presence, Fear, Curiosity, and Other Themes in Community Youth Work. Applied Developmental Science, 2000 Supplement 1, Vol. 4. Mark Krueger (2000), Presence, Fear, Curiosity, and Other Themes in Community Youth Work Applied Developmental Science, Jun2000 Supplement 1, Vol. 4 Issue 3, p21-27 Mark Schoenhals (1998), The Educational and Personal Consequences of Adolescent Employment. Social Forces, Dec98, Vol. 77 Issue 2, p723-762 Paul Osterman (1978), Youth, Work, and Unemployment. May/Jun78, Vol. 21 Issue 2 Robert F. Ashcraft (2000), Where Youth Work Preparation Meets Higher Education: Perspectives From an American Humanics Campus Program. Applied Developmental Science, 2000 Supplement 1, Vol. 4 Sara Banks (1998), Codes of Ethics and Ethical Conduct: A View from the Caring Professions. Public Money Management, Jan-Mar98, Vol. 18 Issue 1, p27 Footnotes [1] Mark Krueger (2000), Presence, Fear, Curiosity, and Other Themes in Community Youth Work. Applied Developmental Science, 2000 Supplement 1, Vol. 4. [2] Peter F. Druker (1990), Managing the non-profit organization : practices and principles, London: Butterworth-Heinemann [3] Robert F. Ashcraft (2000), Where Youth Work Preparation Meets Higher Education: Perspectives From an American Humanics Campus Program. Applied Developmental Science, 2000 Supplement 1, Vol. 4 [4] Paul Osterman (1978), Youth, Work, and Unemployment. May/Jun78, Vol. 21 Issue 2 [5] Mark Schoenhals (1998), The Educational and Personal Consequences of Adolescent Employment.. Social Forces, Dec98, Vol. 77 Issue 2, p723-762 [6] Mark Krueger (2000), Presence, Fear, Curiosity, and Other Themes in Community Youth Work Applied Developmental Science, Jun2000 Supplement 1, Vol. 4 Issue 3, p21-27 [7] Sara Banks (1998), Codes of Ethics and Ethical Conduct: A View from the Caring Professions. Public Money Management, Jan-Mar98, Vol. 18 Issue 1, p27 [8] Abraham Daniel (1999), ESTABLISHMENT OF INDUSTRIAL CO-OPERATIVE UNITS. Annals of Public Cooperative Economics, Vol. 42 Issue 2, p169 [9] Philip Kotler and Kevin Lane Keller (2005), Marketing Management 12e, Prentice Hall India [10] Derek Torrington and Laura Hall (2003), Personnel Management HRM in Action, UK: Prentice Hall [11] Michael Armstrong and Tina Stephens (2003) A handbook of employee reward management and practice, London Kogan Page [12] Andrew Rothwell and John Arnold (2005), How HR professionals rate continuing professional development Human Resource Management Journal, 2005, Vol. 15 Issue 3, p18-32 [13] John A. Calhoun (2002), Claiming youth: A new paradigm in youth policy. New Directions for Philanthropic Fundraising, Winter2002, Vol. 2002 Issue 38, p67-80 [14] Bill Katz (2004), Youth Policy : The Monthly Report on National Youth Program and Issues. Library Journal, 4/1/89, Vol. 114 Issue 6, p119-119 [15] Greater Manchester Metropolitan Police (2004), Performance Statistics

Discovery Of Losartan Potassium Health And Social Care Essay

Discovery Of Losartan Potassium Health And Social Care Essay Losartan is the first angiotensin II receptor antagonist drug to be marketed for use mainly to treat high blood pressure (hypertension). Losartan was first discovered in March 1986 by scientists on their first assignments at a corporate research laboratory, in Du Pont, as DuP 753(Merck 954), a highly potent and orally active non-peptide Ang II receptor antagonist. At the time, DuPont as a company was rather new to pharmaceutical business. The company had previously been dealing in chemicals, but the in the 1970s when the demand for Petroleum and its related products natural gas drove prices high, management attempted to diversify the business by seeking other business avenues to reduce their dependency on chemicals in a hope of also increasing their profit. As a result of creating new business, DuPont had ventured into pharmaceuticals and other life sciences businesses by the 1980s. Losartan work was one of the compounds DuPont research labs worked on. The company being inexperience in this area of business, hired Robert I. Taber, a scientist with two decades of research experience with Schering, to head pharmaceutical research at DuPont.It was Taber who recognized the areas of potentials and encouraged the research team to delve further. However, DuPont being a fairly young company in these areas would lead to other weighty problems, and these issues were quickly settled by a collaboration with the more experienced Merck, who also recognised the Potential of Losartan and convinced DuPont that there was more to be gained by working on Losartan. Development of Losartan was done after a series of efforts. The final market product was Co-Developed with Scientists from both Merck DuPont. [BHARDWAJ, G., 2006] Losartan was approved by the FDA in April 1995, and it was then launched that month as the first non-peptide anti-hypertensive drug in the new class of Ang II receptor antagonists. Merck started selling losartan under the trade names CozaarT and HyzaarT with annual sales in excess of $3 Billion Dollars by 2005. Chemical Structure (IUPAC) nomenclature (2-butyl-4-chloro-1-{[2-(1H-tetrazol-5-yl) biphenyl-4-yl] methyl}-1H-imidazol-5-yl) methanol Chemical data Formula C22H23ClN6O Mol. mass 422.91 Action of Losartan Losartan selectively inhibits all Ang II responses that have been studied and lowered blood pressure in several animal models of renin-dependent hypertension. In animals, the antihypertensive efficacy of losartan has been found to be similar to that of the ACE Inhibitors (Angiotensin Converting Enzyme inhibitors) but, unlike ACE inhibitors, losartan is a more selective inhibitor of the renin-angiotensin system since it does not affect the metabolism of kinins. Compared with peptide Ang II antagonists (e.g. saralasin), losartan has significant advantages, including a long duration of action, effective oral absorption and no Ang II agonist activity. [SIEGL, P.K., 1993] Indications Hypertension Losartan tablets is indicated for the treatment of hypertension. Losartan can be used alone or used in combination with other antihypertensive agents, including diuretics. [Rx LIST THE INTERNET DRUG INDEX., 2009] Hypertensive Patients with Left Ventricular Hypertrophy Losartan is also indicated in patients with hypertension and left ventricular hypertrophy to reduce the risk of stroke, but there has been a study to suggest that Losartan is not beneficial with Black patients in reducing the risk of stroke. [Rx LIST THE INTERNET DRUG INDEX.,2009] In the LIFE study, it was found out that Black patients with conditions of hypertension and left ventricular hypertrophy had a lower risk of stroke on atenolol than on Losartan. However, there was some shortcomings of the LIFE study, as it did not provide evidence that the benefits of Losartan in hypertensive patients with left ventricular hypertrophy by reducing the risk of cardiovascular events applied to Black patients. [Rx LIST THE INTERNET DRUG INDEX.,2009] Nephropathy in Type 2 Diabetic Patients Losartan is also very useful in the treatment of patients with diabetic nephropathy, where there is an elevation of serum creatinine and proteinuria (urinary albumin to creatinine ratio à ¢Ã¢â‚¬ °Ã‚ ¥ 300 mg/g) in patients that have type 2 diabetes and a history of hypertension. In this group, Losartan has been shown to reduce the rate of progression of the nephropathy. This is measured by the occurrence of doubling of serum creatinine or end stage renal disease where there is need for dialysis or renal transplantation. [Rx LIST THE INTERNET DRUG INDEX.,2009] SPECIFIC PRODUCTS ( CONTAINING THIS DRUG) AVAILABLE FOR USE IN GIVEN CONDITION Combination therapy: A combination therapy is used if losartan monotherapy alone is not sufficient to control hypertension. Hence, losartan is available in combination with hydrochlorothiazide in different strengths as follows:[BRITISH NATIONAL FORMULARY., 2009] Losartan 50mg + Hydrochlorothiazide 12.5mg Losartan 100mg + Hydrochlorothiazide 12.5mg Losartan 100mg + Hydrochlorothiazide 25mg. The above combination is used for treatment of high blood pressure and stroke in patients with heart disease. It is a prescription only medicine. [MEDICINES AND HEALTH CARE PRODUCTS REGULATORY AGENCY., 2009] EVIDENCE FOR EFFICACY FOR THIS TREATMENT. Clinical trials have shown a better efficiency of losartan as an antihypertensive by itself and a further higher efficiency in a combined state with hydrochlorothiazide. For example : a double-blind, multicenter, randomized, parallel group study performed on African Americans (who are generally less responsive to monotherapy from any hypertensive class), with severe hypertension have shown a significant reduction in sitting diastolic and systolic blood pressure with losartan monotherapy (45.8%) when compared with placebo (27.2%) . In the same study, the combination losartan/ hydrochlorothiazide regimen showed significant higher reductions (62.7%) in blood pressure compared with losartan monotherapy or placebo. More over, both the regimens i.e losartan monotherapy and the losartan/hydrochlorothiazide were as well tolerated as the placebo[FLACK, et al., 2001]. Other studies were performed on hypertensive patients who had discontinued treatment with calcium channel blockers and angiote nsin converting enzyme inhibitors due to side effects like peripheral edema or dry cough respectively. These patients when treated with losartan have shown as much reduction and control over blood pressure as they use to with previous therapies.[GIOVANNETTI, et al., 1997]. And quite interestingly it has also been observed that the clinical side effects were minimal with losartan treatment and the haematologic and biochemical profiles were also not disturbed. [GIOVANNETTI, et al., 1997] Studies performed on the pharmacokinetics and pharmacodynamic parameters of losartan on healthy male volunteers and also on special patient groups like elderly patients with renal impairment and those having liver disease, suggest that losartan is orally active and its effect lasts for over 24 hours. None of the patient groups showed any significant pharmacokinetic interactions[McINTYRE, et al., 1997]. Losartan 50mg appears to be a safe starting and maintenance dose in most patient populations. However, when an additive effect is required, it can be easily combined with thiazide diuretics to achieve the target blood pressure. Losartan has low discontinuation rate and it has also been observed that it was not associated with cough even in patients who experience this side effect with to ACE inhibitors [McINTYRE, et al., 1997]. A BRIEF COMPARISON WITH OTHER MEDICINAL PRODUCT USED TO TREAT THE SAME AILMENT Losartan potassium, is an angiotensin receptor antagonist (AT1) used in the treatment of hypertension and other cardiovascular diseases. However, a comparison with other ARB(e.g. valsartan and candesartan) shows that, these drugs have the same mechanism of action, though, their differences in pharmacokinetic profile may be responsible for their differences in efficacy in the treatment of hypertension. Losartan and valsartan when compared, exhibited a similar reduction in blood pressure at a lower concentration ,however, valsartan has a higher response rate and more effective 24hours blood pressure control rate at the dose of 160mg and 80mg respectively than losartan at 100mg and 50mg respectively.[BURNIER BRUNNER 2000]. Candesartan 8mg and 16mg has also demonstrated a more lasting antihypertensive effect than losartan 50mg and 100mg in ambulatory BP monitoring.[LACOURCIERE ASMAR 1999] A brief comparison with other medicinal products from the other class like B- adrenergic blocker(e.g. atenolol), ACEI(e.g. enerlapril), calcium channel blocker(e.g. felodipine) and diuretics were based on the efficacy, tolerability and safety in the treatment of essential hypertension. Losartan , when compared with amilodipine has been shown to exhibit a similar clinically relevant reduction in patients with systolic blood pressure, however, losartan was better tolerated as evidenced by fewer clinically adverse effect(CAE)and discontinuation compare with amlodipine [VOLPE, et al., 2003]. Meanwhile, in the contrasting effect of losartan, nifedipine GIT, and fosinopril on the ambulatory blood pressure, cardiac structure and function, and protective function of the endothelium in patients with essential hypertension, nifedipine GIT is superior to others in plate- granule membrane protein (GMP), while fosinopril and losartan had a preffered action to nifedipine GIT in reversing ventricul ar hypertrophy, however, losartan was better tolerated than the other drugs [QI XIURONG 2001]. Losartan potassium has been known to exhibit a fewer drug related adverse effect in contrast to other medicinal products in the other classes used in the treatment of hypertension. [GOLDBERG, et al., 1995] In summary, losartan potassium has an excellent tolerability profile in patient with essential hypertension and, in a demographic sub group of elderly versus young, women versus men and black versus non black; it has been shown to have an excellent safety profile. ADVANTAGES OF LOSARTAN POTASSIUM. Side effect; In the treatment of hypertension, losartan has exhibited fewer drug related side effect when it was compared with other class of antihypertensive agents .[GOLDBERG, et al., 1995] Tolerance; when compared in patients with essential hypertension, losartan was better tolerated than other agents from the other class and hence an excellent tolerability profile. Safety profile; It has a good safety profile in a demographic sub groups. It doesnt produce rebound high blood pressure when it is withdrawn. DISADVANTAGES OF LOSARTAN POTASSIUM. 1 Losartan has been associated with some damaging effect on the foetus which may include reduced body weight, death and kidney injuries hence it is contraindicated in pregnancy. [GOLDBERG, et al., 1995] Analysis of the market potential for the development of new drug candidates to treat the given condition Development of new drug products has always been a challenging task. Growth in technology resulted in an evolution in pharmaceutical world and has paved way for research and development to meet demands for more efficient products. About one billion people have been affected by hypertension world wide and reports also says that in US alone 65 millions people are affected by high blood pressure.[SMITH ASHIYA 2007]. This indicates the level of demand of antihypertensives world wide. Efforts have been made and many potential drugs have been developed till date. However the expiry of patents of angiotensin receptor blockers (ARB) opened doors for arrival of cheap generic products which resulted in a threat to the global pharmaceutical market. Data monitoring of the sales of antihypertensives in seven major global markets (i.e UK, France, US, Italy, Spain, Germany and Japan ) predicted sales of upto $ 29.5 billions by 2018, which would be a drop of $6 billion when compared to that of 2008. Considering above threats, the big pharmaceutical companies are under an impression that it is not worth to spend on research and development of novel therapies and they appear to be moving away from investing in research and development to develop more efficient antihypertensive therapies. [THE MEDICAL NEWS., 2009] Product Name Patent Number Patent Expiration Mercks COZAAR (losartan potassium) 5,138,069*PED  Ã‚   11 Feb,2010 Mercks COZAAR (losartan potassium) 5,153,197*PED   06 Apr, 2010 Mercks COZAAR (losartan potassium) 5,210,079*PED  Ã‚   11 Nov,2010 Table showing the expiry of patent of COZAAR (losartan potassium) Angiotensin receptor blocker. [DRUG PATENT WATCH., 2010] Short comings of the existing treatment to justify new drug development Though antihypertensive agents were able to achieve significant control over hypertension induced morbidity and mortality, still there is much to be done. For example: disappointments associated with coronary artery disease, risk of cardiovascular events even after treatment with antiphyertensive agents and comparatively higher possibility of cardiovascular events in hypertensive patients compared to normotensive patients. These effects are thought to be due to inability of existing antihypertensives to reverse other associated factors like left ventricular hypertrophy, negative metabolic effects and risk associated with overtreatment.[HANSSON, L., 1991]. Hence there is a need for an ideal hypertensive agent which may be able to control blood pressure to normotensive levels whilst being free of negative metabolic effects. Moreover, it should also be able to reverss cardiovascular changes like cardiac hypertrophy and control tissue damage in case of possible vascular complications. [H ANSSON, L., 1991]. Analysis of data available on search engines indicates the promising role of upcoming gene therapy and nano-technology to produce new drug candidates. For example: Exploring areas like gene transcripton, molecular genetic regulation of blood pressure ( targeting genetic risk factors as in cases of essential hypertension) appears to be a new hope for future developments of antihypertensives.[KURTZ GARDNER 1998] Possible potential for new therapy. Research is currently being carried out to explore the potential of upcoming gene therapy and nano-technology to produce new drug candidates. For example: Areas like gene transcripton, molecular genetic regulation of blood pressure ( targeting genetic risk factors as in case of essential hypertension) appears to be a new hope for future developments of antihypertensives.[KURTZ GARDNER 1998]. However alternatively, combination products containing antihypertensives and statins could be a new hope for future developments. à ¢Ã¢â€š ¬Ã‚ ¦Ãƒ ¢Ã¢â€š ¬Ã‚ ¦Ãƒ ¢Ã¢â€š ¬Ã‚ ¦Ãƒ ¢Ã¢â€š ¬Ã‚ ¦Ãƒ ¢Ã¢â€š ¬Ã‚ ¦Ãƒ ¢Ã¢â€š ¬Ã‚ ¦Ãƒ ¢Ã¢â€š ¬Ã‚ ¦

July’s People by Nadine Gordimer Essays -- Julys People Nadine Gordim

"July’s People" by Nadine Gordimer In July’s People, Nadine Gordimer gives a very detailed and knowledgeable explanation of the political turmoil within South Africa. By expressing the emotions of a family involved in the deteriorating situation and the misunderstandings between blacks and whites, she adds a very personal and emotional touch, which allows the reader to understand the true horror and terror these people experienced. Gordimer writes of how the Smales family reacts, survives, and adjusts to this life altering experience. She makes obvious throughout the book that prejudice plays a major role in uncovering the reactions of Bamford and Maureen Smales. The Smales were a suburban, upper middle class, white family living in Southern Africa until political turmoil and war forced them to flee from their home and lives. Rebel black armies in Soweto and other areas of Southern Africa revolted against the government and the minority white race, attacking radio and television stations and burning the homes of whites. The Smales needed to get out quickly. Their servant July, whom they had always treated well and had a very uncommon relationship with, offered to guide the family to his village. The Smales, having no other options, accepted July’s offer and ran in haste and confusion to the dearth village. They knew little of the drastic adjustments they would have to make in order to survive in July’s rustic village. These adjustments would soon threaten their relationships with one another and their family’s structure. The three Smales children, Victor, Royce and Gina, had not experienced, and therefore had not expected to live a life of luxury amongst people of their â€Å"own† kind. This innocence contributes greatly to the rate and comfort in which they adjust to living in July’s village. Bam and Maureen may not have felt prejudice towards the black race, but were certainly prejudice about the lifestyle in which they must now live, a lifestyle completely stripped of any and all luxuries they once enjoyed. All of the family members, facing a new way of life, adjust to their situation in radically different ways. Each one drifts in their own direction in search of comfort and acceptance throughout their experiences living amongst July’s people. The first adjustment the Smales family had to make was the realization that they no longer had all of ... ...and towards the sound of the helicopter, towards the hope of renewal. Because of Maureen’s flight from the village and from any responsibilities she once had, Bam must now become the mother figure of the family, nurturing his children and taking on what was once her role. July’s People is a story of the reactions, adaptations, and survival of Bamford and Maureen Smales to the life they have found in a black village after being thrown from their middle-class white neighborhood. Bam’s adjustment to their new life in the village was much better than Maureen’s because he handled the situation rationally by attempting to become a part of the community without letting his emotions get the best of him. Maureen, on the other hand, could not adjust to the situation and went almost completely insane because she could not accept a life without racial and gender structures. This alteration in her lifestyle was completely unbearable and she couldn’t survive without the power, control, and luxuries she once had. As a result of the radically different reactions and adaptations of Bam and Maureen to the life in July’s village, their relationship with one another was completely disintegrated.

The Vices of Human Nature in Homers The Odyssey Essay -- World Litera

The sum of all human traits is defined as human nature, meaning the excuse for our vices, and the flaws of mortal life. In Homer's The Odyssey, the main character Odysseus demonstrates these flaws throughout his journey, constantly struggling through the eternal fight for realization of life and death, and is weighed down by the never ending power struggle of nature versus mankind. In The final chapters of Odysseus's quest, the reader believes that the main character has finally found himself. The problem with his happy ending is that he has forgotten one thing. Odysseus is not perfect he is human. Though he has learned much through his perils, the vices of Pride, vengeance, and dependency, all come back to haunt him during the slaughter in the hall, leaving the reader to wonder if he learned anything during his time away from home. What if the true lesson learned was that human nature will always prevail? In book twenty-two, when Odysseus is preparing to slaughter the suitors, he exclaims, murdering bow in hand: "Look-your crucial test is finished, now at last! But look ...

ALS DISEASE Oral Notes :: essays research papers

ALS- Amyotrophic lateral sclerosis Lou Gehrig’s disease- Yankee B-Ball player 1903-1941 Neurodegenerative disease- Unknown cause breaks tissue down in nervous system. Motor Neurons- they control muscle movement Affects nerves from the brain to the spinal cord (upper motor neurons) then the lower spinal cord (lower motor neurons) which control muscle movement. With this disease, for unknown reasons, these neurons die, meaning a progressive loss of the ability to move nearly any of the muscles in the body. Lou Gehrig’s disease affects voluntary muscles, controlled by conscious thought, such as the arm, leg, and trunk muscles. ALS DOES NOT affect the heart muscle, or the â€Å"smooth† muscle of the digestive system, bladder, and other internal organs. Most keep eye movement as well. â€Å"Amyotrophic†- means the loss of muscle bulk. â€Å"Lateral† indicates the spinal cord being affected. â€Å"Sclerosis† describes hardened tissue that develops in the place of healthy nerves. 50,000 approximately people in the US, 5,000 new cases each year. Onset between ages 40-70, usually. Men have a slightly higher chance of developing ALS. Normally, neurons in the spinal cord and brain convey messages from the brain to muscles to give movement to the arms, legs, trunk, neck, and head. When the motor neurons die, the muscles can’t move, with weakness in result. Loss of bulk is also a symptom. Loss of Lower motor neurons can make twitching. Two forms are known- Familial and sporadic. Familial accounts for about 10% of all Lou Gehrig’s cases. Sporadic LGD has no known cause. The earliest sign of LGD is weakness in arms or legs, and the throat and mouth muscles.-Speech slurred, hard to chew and swallow. Other early signs are twitching and muscle loss. Later symptoms lead to the loss of the ability to walk, use arms and hands, to speak clearly or at all, to swallow, and to hold the head up. Eventually coughing and breathing become difficult.

High school versus college Essay

Going to College after so many years made me realize how different high school is from College. In fact, many students that attend College straight after high school quit after their first semester of College due to the changes and difficulties encountered. There are various reasons why College differs from high school. However, knowing the expectations and the culture of College in comparison to high school would help in a more successful transition. College differs from high school in many ways. However, students should begin their transition to College by first looking at not only what to expect from College; but also what College will expect from them. As a college education is very important step to reach personal aspirations in the workplace and life. First of all, College offers an opportunity to learn independently. Unlike high school, College students can function with little guidance from their professors. As a result, College students have to develop many self management skills such as getting to school on time, turning projects by deadlines, being able to use electronic materials for the syllabus, class outlines, online classes or assignments. Secondly, College has a faster pace than high school. Each college course is twice faster than high school courses. In addition, College course usually requires more reading, more homework, and more projects. The workload is totally higher and faster and requires more time to study. The College books have more words per page, thus more chapters than the high school books. The language used in the textbooks is more difficult and requires more time to study. Unlike high school which has specific school hours 5 days a week excluding weekends; College on the other hands offer more out of class time. Students can choose to go to school any time based on their chosen schedule whether is day, night or weekends. As a result of this freedom, College students have to learn to manage their time effectively. In addition, all high schools students must take the same basic classes in order to graduate such as English, Mathematics, Sciences, Physical education, world history, economics, foreign languages and other elective. College students on the other hand can take any classes based on their academic major. Most college freshmen start with beginning classes such as English, writing, speech, and Mathematics then they can choose any other required course based on their academic field of study. College students also have higher level of thinking than high school students. They are able to do research on a topic and ideas as well as analyzing others ideas and interpreting and evaluating data from any given source. High school students on the other hands can only summarize and take ideas from others. Some of College student’s classes unlike high school class require research papers, presentation, and discussion in front of the whole class and sometimes peer evaluation. Although College culture differs widely from high school culture, students can also succeed with improved effort and practice. Whether students attend College straight from high school or its equivalents; or attending College after many years of working, going to college offers an opportunity to grow and to achieve goals. No matter what the background or motivation, being a College student will provide an opportunity to improve life and reach personal aspirations.

Pepsi Mission and Swot Analysis

Wendy Montagno Mkt-3120-401 Firm Mission didactics PepsiCo. Pepsi has had a long and rich account. The befuddle was invented by Caleb Bradham, a pharmacist in New Bern, North Carolina. He patent the drink and launched the Pepsi-Cola follow in1902, from the back way of life of his pharmacy. It developed into a strong immunity system. The dedication of the local Pepsi-Cola bottlers, have stomachd a solid foundation. Pepsis mission has forever and a day been to be a responsible incorporated citizen. They strive to be the worlds premier consumer products company, focused on handy foods and beverages.They work at producing financial rewards for its investors. They provide opportunities for growth for their employees and partners. Above all, they make any effort for honesty, fairness and integrity. Pepsi states their vision on their website as PepsiCos responsibility is to continually amend all aspects of the world in which we expire environment, social, economic creating a meliorate tomorrow than today. They wish to create programs and focus on environmental stewardship to benefit the society. They in addition lack to build shareholder value by becoming a truly sustainable company.Pepsi is the worlds second largest beverage and food company based on its net revenue. In North the States it is first largest Beverage and Food Company by net revenue. SWOT analysis of PepsiCo. Internal Strengths One of Pepsis strengths is its history with a longtime local home. They overly have a long stand up loyal customer base. They also clutch on top of current engineering science systems and networks to manage their manufacturing and distribution. Pepsi prides itself on knowing their customers ask to provide excellent customer usefulness and implement global growth. WeaknessesPepsi must keep an eye on chain stores. set up stores have a trim per-unit salute and can provide a lower price for their items. Pepsi has also had problems with offering crude p roducts without having sufficient knowledge of their target demographic. Their size is also a concern. The company is so large that it could lose focus or have internal conflict problems immaterial Opportunities Pepsi needs to utilize the expanding Internet possibilities to better serve their customers. This goes in hand with providing reproduction to their employees as systems become more complicated.They could also better position themselves to provide excellent personal service to compete with incase stores since the large store seem to be driven by sales. Threats Pepsi always faces a challenge from their largest competitor, Coke whom has the worlds largest beverage distribution. On the new(prenominal) post they deal with competition from General mill around and ConAgra which are striving to have a larger market share in the snack market. Pepsi also faces the challenge of divergent regulations and policies set by governments in other countries.